Rosetta@Home Project

From Unofficial BOINC Wiki

Contents 1 General 2 Reading List for Protein Folding Related Projects 3 More About Rosetta@Home 4 Project information 5 Also See 6 Active BOINC Projects

[edit] General

A BOINC Powered Project that is modeling the "folding" of protein structures that may lead to medical advances in the near future.

Rosetta@Home is a scientific research project that uses Internet-connected computers to predict and design protein structures, and protein-protein and protein-ligand interactions. Our goal is to develop methods that accurately predict and design protein structures and complexes, an endeavor that may ultimately help researchers develop cures for human diseases (See the Human Protein Folding Project, a collaborative effort to apply our software on the human genome). Our project relies on individuals, like you, who donate time on their computers to collectively provide the computing power necessary to further develop, test, and improve our methods.

To get you going, we have the general topic, "The Science Behind Rosetta@Home, An Introduction To Protein Folding".

[edit] Reading List for Protein Folding Related Projects

Regrettably, there is somewhat confusing vocabulary necessary to begin a discussion of the Rosetta@Home method of protein folding, as well as comparisons of this approach with other related BOINC Powered Projects: Poem@Home, Folding@Home, Predictor@Home, Rosetta@Home, SIMAP@Home, and World Community Grid.

• Proteins
• Protein Structure
• Protein Folding

[edit] More About Rosetta@Home

• Getting started with Rosetta@Home
• Rosetta@Home FAQ
• The Science Behind Rosetta@Home, An Introduction To Protein Folding
• What Is The Difference Between The Different Protein Projects; Including Folding@Home, Predictor@Home, Rosetta@Home, SIMAP, and World Community Grid?
• How much resource share should I give to Rosetta@Home?
• More about the Rosetta@Home Science
• Quick guide to Rosetta and its graphics
• Problems Running - How-To Test Machine Stability

[edit] Project information

• Science:
  • Results are publicly available/not-for-profit
• Credits:
  • Credit isn't artificially inflated.
  • Credit is granted instantly
  • Credit is granted statically
• Size
  • The project has over 50,000 active participants
• Well-run:
  • The project admins participate in the forums, and there is much info availale
  • The project doesn't have a lot of outages/problems.
• Other:
  • The project isn't very original, there are many other protein-folding projects.

[edit] Also See

• Rosetta@Home
• Sixth Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction

[edit] Active BOINC Projects

These BOINC Powered Projects are in the production phase. They are considered reasonably stable and are doing valid science. Alpha and Beta Projects are less stable and not recommended for general Participation.

Wiki Project Page	Project Web Site	Project Goal or Comments
ABC@Home	ABC@Home Web Site	This project will try to find abc triples related to the ABC conjecture.
BBC Climate Change Experiment	BBC Climate Change Experiment Web Site	Study of transient climate change model predictions. As of 10.12.2006, this project is closed for new users. New users should join the main Climateprediction.net (CPDN) project instead.
Climateprediction.net (CPDN)	Climateprediction.net Web Site	Study of Climate Models to answer some of the important Climate Change Questions. Note: Only works with Version 5.x.x or later of the BOINC Client Software.
Seasonal Attribution Project	Seasonal Attribution Project Web Site	High resolution variant of CPDN, taking a more in depth look at certain regional areas. As of December 2007, out of work again with no current plans of a 3rd. extension.
Einstein@Home	Einstein@Home Web Site	Search for gravitational waves to reveal the presence of neutron stars (pulsars).
Leiden Classical	Leiden Classical Web Site	Desktop Computer Grid dedicated to general Classical Dynamics for any scientist or science student.
LHC@Home	LHC@Home Web Site	Model and improve the design of the CERN, LHC particle accelerator. Has work infrequently.
MalariaControl.net	MalariaControl.net Project Web Site	The MalariaControl.net project is an application that makes use of network computing for stochastic modelling of the clinical epidemiology and natural history of Plasmodium falciparum malaria. Also see: Africa@Home
Predictor@Home	Predictor@Home Web Site	Investigate protein behavior. As of February 2007 is beta-testing a new application.
Rosetta@Home	Rosetta@Home Web Site	Predict and design protein structures, and protein-protein and protein-ligand interactions using the Rosetta program.
SETI@Home	SETI@Home Web Site	Look for radio evidence of extraterrestrial life.
SIMAP@Home	SIMAP@Home Web Site	Study of protein similarities. Has work infrequently, check home page for more info.
SZTAKI Desktop Grid	SZTAKI Web Site	Hungarian project. This project is exploring a mathematical domain looking for solutions to a particular problem space.
World Community Grid	World Community Grid Web Site	Runs multiple sub-projects, users can choose which project(s) to run. Note: Only works with Version 5.x.x or later of the BOINC Client Software.