Rosetta@Home Project

From Unofficial BOINC Wiki

Rosetta@Home - http://boinc.bakerlab.org/rosetta/ - Rosetta@home tries to determine the 3-dimensional shapes of proteins in research that may ultimately lead to finding cures for some major human diseases. By running the Rosetta program on your computer you will help to speed up and extend our research in efforts at designing new proteins to fight diseases such as HIV, Malaria, Cancer, and Alzheimer's disease.

Contents 1 General 2 System requirements 2.1 Microsoft Windows 2.2 Macintosh 2.3 Linux (32-bit) 2.4 BOINC Client 3 Reading List for Protein Folding Related Projects 4 More About Rosetta@Home 5 Project information 6 Also See

[edit] General

A BOINC Powered Project that is modeling the "folding" of protein structures that may lead to medical advances in the near future.

Rosetta@Home is a scientific research project that uses Internet-connected computers to predict and design protein structures, and protein-protein and protein-ligand interactions. Our goal is to develop methods that accurately predict and design protein structures and complexes, an endeavor that may ultimately help researchers develop cures for human diseases (See the Human Protein Folding Project, a collaborative effort to apply our software on the human genome). Our project relies on individuals, like you, who donate time on their computers to collectively provide the computing power necessary to further develop, test, and improve our methods.

To get you going, we have the general topic, "The Science Behind Rosetta@Home, An Introduction To Protein Folding".

[edit] System requirements

(Operating System, CPU speed, Available Disk, Memory)

[edit] Microsoft Windows

• Windows XP 500MHz or higher 800MB 1024M
• Windows 2003 Server 500MHz or higher 800MB 1024M
• Windows 2000 500MHz or higher 800MB 1024M

[edit] Macintosh

• Mac OS X 10.3.9, or later (PPC is gradually being phased out) at least 350MHz G3 800MB 1024M

[edit] Linux (32-bit)

• Red Hat Linux 8.X, 9.X 500MHz or higher 800MB 1024M
• Mandrake Linux 10.x 500MHz or higher 800MB 1024M
• Debian Linux 3.0 500MHz or higher 800MB 1024M

[edit] BOINC Client

The latest version of the BOINC client is recommended. BOINC version 4.19 is not supported.

[edit] Reading List for Protein Folding Related Projects

Regrettably, there is somewhat confusing vocabulary necessary to begin a discussion of the Rosetta@Home method of protein folding, as well as comparisons of this approach with other related BOINC Powered Projects: Poem@Home, Folding@Home, Predictor@Home, Rosetta@Home, SIMAP@Home, and World Community Grid.

• Proteins
• Protein Structure
• Protein Folding

[edit] More About Rosetta@Home

• Getting started with Rosetta@Home
• Rosetta@Home FAQ
• The Science Behind Rosetta@Home, An Introduction To Protein Folding
• What Is The Difference Between The Different Protein Projects; Including Folding@Home, Predictor@Home, Rosetta@Home, SIMAP, and World Community Grid?
• How much resource share should I give to Rosetta@Home?
• More about the Rosetta@Home Science
• Quick guide to Rosetta and its graphics
• Problems Running - How-To Test Machine Stability

[edit] Project information

• Science:
  • Results are publicly available/not-for-profit
• Credits:
  • Credit isn't artificially inflated.
  • Credit is granted instantly
  • Credit is granted statically
• Size
  • The project has over 50,000 active participants
• Well-run:
  • The project admins participate in the forums, and there is much info availale
  • The project doesn't have a lot of outages/problems.
• Other:
  • The project isn't very original, there are many other protein-folding projects.

[edit] Also See

• Rosetta@Home
• Sixth Community Wide Experiment on the Critical Assessment of Techniques for Protein Structure Prediction